OAK BROOK, Ailing., Nov. 24, 2020 /PRNewswire/ — A typical weight reduction surgical procedure for adolescents with weight problems referred to as sleeve gastrectomy has dangerous results on bones, based on a examine being introduced on the annual assembly of the Radiological Society of North America (RSNA).
“Childhood weight problems is a significant public well being concern that has elevated over the past 10 years,” mentioned lead investigator Miriam A. Bredella, M.D., professor of radiology at Harvard Medical Faculty in Boston, Massachusetts, and vice chair of the Division of Radiology at Massachusetts Normal Hospital in Boston. “Sleeve gastrectomy is the commonest bariatric surgical procedure process carried out in youngsters and adults.”
In a sleeve gastrectomy, roughly 75% of the abdomen is eliminated to limit meals consumption and induce weight reduction. It leads to a sometimes spherical abdomen taking up the form of a tube or sleeve. The variety of sleeve gastrectomy procedures carried out on adolescents elevated 100-fold from 2005 to 2014.
“In adults, bariatric surgical procedure can have long-term results on bone, resulting in greater fracture threat,” Dr. Bredella mentioned. “We wished to find out the consequences of sleeve gastrectomy carried out on adolescents through the essential years when bone mass is being accrued.”
The examine examined 52 adolescents with average to extreme weight problems, 26 of whom underwent sleeve gastrectomy. The opposite 26 have been within the management group. Imply age was 17.5 years, and imply physique mass index (BMI) was 45. BMI of 30 or above is taken into account overweight. Thirty-eight of examine members have been women. Earlier than and 12 months after sleeve gastrectomy (or no surgical procedure), the sufferers underwent quantitative CT of the lumbar backbone, to quantify volumetric bone mineral density. Quantitative CT is a extremely correct method for detecting adjustments in volumetric bone mineral density after excessive weight reduction.
Latest research have proven that bone marrow fats responds to adjustments in diet and should function a biomarker for bone high quality. Due to this fact, sufferers underwent proton MR spectroscopy to quantify bone marrow fats of the lumbar backbone.
One yr following surgical procedure, the adolescents who underwent sleeve gastrectomy misplaced 34 (+/-13) kg, or 75 (+/-28) kilos, whereas there was no vital change in weight within the management group. In comparison with the controls, sleeve gastrectomy sufferers had a big enhance in bone marrow fats and a lower in bone density within the lumbar backbone.
“Adolescents who underwent sleeve gastrectomy had bone loss and a rise in bone marrow fats, regardless of marked lack of physique fats,” Dr. Bredella mentioned. “Whereas weight-loss surgical procedure is profitable for weight reduction and bettering metabolic problems, it has adverse results on bone.”
Dr. Bredella mentioned the lack of bone density following sleeve gastrectomy was anticipated as a result of higher weight-bearing strengthens bones. Along with a lack of bone density, different results of weight-loss surgical procedure embrace a disruption of hormones and vitamins essential for bone well being.
“We have to establish mechanisms that may assist stop bone loss in these sufferers and to make adolescents with weight problems extra conscious of bone well being,” she mentioned. “Adolescence is the important time for bone mass accrual, and any course of that interferes with bone accrual throughout this time can have dire penalties later in life.”
Co-authors are Vibha Singhal, M.D., Nazanin Hazhir Karzar, M.D., Abisayo Animashaun, B.S., Amita Bose, B.S., and Madhusmita Misra, M.D., M.P.H.
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SOURCE Radiological Society of North America (RSNA)