On this installment of “Your Questions Answered,” Christoph Correll, MD, and Sanjai Rao, MD, reply to questions requested by attendees of a Psych Congress 2020 session they offered on managing weight achieve and metabolic disruptions in sufferers with schizophrenia.
Dr. Correll is Professor of Psychiatry and Molecular Drugs, the Donald and Barbara Zucker College of Drugs at Hofstra/Northwell, Hempstead, New York. Dr. Rao is Affiliate Medical Professor of Psychiatry and Affiliate Residency Coaching Director, College of California, San Diego and VA San Diego Healthcare System.
Q: In sufferers on long-acting injectables (LAIs), what do you counsel apart from the addition of metformin to assist with weight, when way of life adjustments are a problem? What else may I do to assist management the metabolic results?
Dr. Correll: In case that metformin is ineffective or the affected person doesn’t tolerate it, adjunctive topiramate might be tried. Alternatively, a change to a decrease cardiometabolic threat antipsychotic might be tried.
Q: Have there been any findings concerning weight change in sufferers switching from olanzapine to ALKS 3831?
Dr. Correll: The two accessible research that may inform this query counsel that there will probably be no weight reduction when switching from olanzapine to olanzapine/samidorphan (ALKS 3831), however that the load achieve will plateau.
Q: How does lumateperone differ from different weight impartial antipsychotics akin to cariprazine or lurasidone?
Dr. Correll: There aren’t any direct comparisons between lumateperone and cariprazine or lurasidone, which will probably be necessary to carry out. Nonetheless, the accessible placebo-controlled research and people who included risperidone as one other energetic arm counsel that lumateperone will probably be at the least as cardiometabolically secure as cariprazine and lurasidone.
Q: Are you able to advocate any explicit instructional supplies about schizophrenia which might be useful to sufferers?
Dr. Rao: A very good place for sufferers to begin on the lookout for info on schizophrenia (or another psychological sickness) is the Nationwide Alliance on Psychological Sickness (NAMI) web site. They’ve descriptions of every of the diseases in simple to grasp language, together with info on prognosis, therapy, and assist. Right here is the hyperlink to the reason on schizophrenia: https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Schizophrenia.
On this occasional characteristic, members of the Psych Congress Steering Committee and school reply questions requested by attendees on the Psych Congress household of conferences.